Biomarker alteration following chemotherapy-based systemic therapy in de novo metastatic breast cancer
Changes in ER, PR, HER2, and Ki-67 status were observed in patients following CST. Positive conversion of ER and PR, and persistent positive expression of HER2 and Ki-67 may indicate a poor prognosis. Further research is needed to determine whether biomarker expression investigations are needed following CST to optimize treatment options and improve survival.
Authors
- Ren Chongxi (ORCID: https://orcid.org/0000-0002-4943-2766)
- Lingjun Kong (ORCID: https://orcid.org/0000-0002-6854-4202)
Institutions
- Cangzhou Central Hospital (CN)
- People's Hospital of Cangzhou (CN)
Publication Details
- Journal
- The Breast
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1016/j.breast.2025.104471
- Citations
- 1
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05