Shenxiong Yixin Decoction polysaccharides exert therapeutic effects against myocardial ischemia-reperfusion injury via intestinal exosomal microRNA-21 regulation
SXYXP may protect against MIRI by targeting miR-21 in intestinal cell-derived exosomes, which are transported to the heart through the blood to restore the level of miR-21 in the damaged myocardium, thereby inhibiting oxidative stress and the expression of PDCD4.
Authors
- Ruizhi Zhao
- J Li
- Shang-Bing Zhang
- Wenjie Mo
- Jienan Luan
- Yan Wang (ORCID: https://orcid.org/0000-0002-7136-9353)
- Yun-Da Yao
- Fan Zheng (ORCID: https://orcid.org/0000-0002-4403-112X)
- Q Y Li
- Pingli Mo (ORCID: https://orcid.org/0000-0002-4913-2042)
- Ying Xie (ORCID: https://orcid.org/0000-0002-8846-4023)
- Hua Zhou (ORCID: https://orcid.org/0000-0002-7025-3690)
- Jianping Chen (ORCID: https://orcid.org/0000-0003-1892-9355)
- Yuanyuan Li (ORCID: https://orcid.org/0000-0002-0405-2268)
- Mingtai Chen (ORCID: https://orcid.org/0000-0003-4579-5559)
- Zirui Li (ORCID: https://orcid.org/0000-0002-6679-8006)
- XU De-sheng
- Qidi Sun
- F Pi
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Dongguan People’s Hospital (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
Publication Details
- Journal
- Pharmacological Research
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1016/j.phrs.2025.107725
- Citations
- 6
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 8.83