Bile acid metabolism in multiple sclerosis is perturbed and associated with the risk of confirmed disability worsening
This study identified alterations in serum BA profiles in pwMS compared to controls, with strong associations between conjugated BAs and the risk of disability worsening. These findings underscore the potential role of BAs in MS pathogenesis and disability worsening, suggesting they may be promising targets for future therapeutic interventions. Further research is warranted to clarify the underlying mechanisms of these associations.
Authors
- Torbjörn Åkerfeldt (ORCID: https://orcid.org/0000-0003-0214-596X)
- Tomas Olsson (ORCID: https://orcid.org/0000-0002-2938-1877)
- Ida Erngren (ORCID: https://orcid.org/0000-0001-7867-9525)
- Aina Vaivade (ORCID: https://orcid.org/0000-0002-1608-2130)
- Ingrid Skelton Kockum (ORCID: https://orcid.org/0000-0002-0867-4726)
- Lars S. Alfredsson (ORCID: https://orcid.org/0000-0003-1688-6697)
- Kim Kultima (ORCID: https://orcid.org/0000-0002-0680-1410)
- Anna Karin Hedström (ORCID: https://orcid.org/0000-0002-6612-4749)
- Joachim Burman (ORCID: https://orcid.org/0000-0002-7045-1806)
- Asma Al-Grety (ORCID: https://orcid.org/0009-0006-9608-4297)
- Henrik Carlsson (ORCID: https://orcid.org/0000-0002-6748-6119)
Institutions
- Uppsala University (SE)
- Karolinska University Hospital (SE)
- Uppsala University Hospital (SE)
- Karolinska Institutet (SE)
- Department of Medical Sciences (RU)
- Centre for Palaeogenetics (SE)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1186/s12916-025-04041-x
- Citations
- 6
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- Åke Wiberg Stiftelse
- Swedish Foundation for MS Research
- Svenska Forskningsrådet Formas
- Svenska Sällskapet för Medicinsk Forskning
- Vetenskapsrådet
- Stiftelsen Lars Hiertas Minne
- Magnus Bergvalls Stiftelse
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Uppsala Universitet
- Svenska Läkaresällskapet
- Marcus och Amalia Wallenbergs minnesfond
- Region Uppsala