Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes
This study reveals a broad convergence in genetic adaptation to hypoxia between natural populations and tumors, suggesting that insights from natural populations could enhance our understanding of cancer biology and identify novel therapeutic targets. See related commentary by Lee, p. 875.
Authors
- Christopher A. Muir (ORCID: https://orcid.org/0000-0002-1430-0499)
- Beatriz Lecumberri
- Tamara Cubiella
- Anne‐Paule Gimenez‐Roqueplo (ORCID: https://orcid.org/0000-0002-4816-670X)
- Anna Casteràs (ORCID: https://orcid.org/0000-0003-4719-065X)
- Juan José Alba‐Linares (ORCID: https://orcid.org/0000-0001-7189-7685)
- José Juan Pozo‐Kreilinger (ORCID: https://orcid.org/0000-0001-5895-4112)
- José-Ángel Robles-Guirado (ORCID: https://orcid.org/0000-0002-7654-7446)
- Francisco Buendía Fuentes (ORCID: https://orcid.org/0000-0003-0616-2986)
- Donate Weghorn (ORCID: https://orcid.org/0000-0001-7722-8618)
- Mirko Peitzsch (ORCID: https://orcid.org/0000-0002-2472-675X)
- Debayan Datta (ORCID: https://orcid.org/0000-0002-2347-0860)
- Judith Favier (ORCID: https://orcid.org/0000-0001-8190-5853)
- Irina Bancos (ORCID: https://orcid.org/0000-0001-9332-2524)
- Paxton V. Dickson (ORCID: https://orcid.org/0000-0002-2345-983X)
- Craig S. Broberg (ORCID: https://orcid.org/0000-0002-9797-9803)
- Ana Belén Moreno-Cárdenas (ORCID: https://orcid.org/0000-0001-7743-3873)
- Rodrigo Almeida Toledo (ORCID: https://orcid.org/0000-0003-3070-6795)
- María Jesús del Cerro Marín (ORCID: https://orcid.org/0000-0001-8616-8768)
- Eduardo García‐Galea (ORCID: https://orcid.org/0000-0003-4699-0786)
- Carmela Iglesias (ORCID: https://orcid.org/0000-0002-4113-676X)
- Roberta Fasani (ORCID: https://orcid.org/0000-0003-1630-9988)
- Yanli Ding (ORCID: https://orcid.org/0000-0001-9554-0461)
- Trisha Dwight (ORCID: https://orcid.org/0000-0003-1943-4514)
- Nicole Bechmann (ORCID: https://orcid.org/0000-0002-6932-333X)
- Bruna Calsina (ORCID: https://orcid.org/0000-0002-6922-9415)
- Josep Villanueva (ORCID: https://orcid.org/0000-0003-1396-9470)
- Isaac Martínez-Bendayán (ORCID: https://orcid.org/0000-0003-3967-8022)
- William F. Young (ORCID: https://orcid.org/0000-0001-5481-4884)
- Emmanuel Esquivel (ORCID: https://orcid.org/0000-0003-1219-2508)
- Elvira Garrido‐Lestache (ORCID: https://orcid.org/0000-0002-2535-5073)
- Jaume Capdevila (ORCID: https://orcid.org/0000-0003-0718-8619)
- Shahida K. Flores
- Mercedes Robledo (ORCID: https://orcid.org/0000-0001-6256-5902)
- S. P. A. Toledo (ORCID: https://orcid.org/0000-0002-2590-3519)
- Mario F. Fraga (ORCID: https://orcid.org/0000-0001-8450-2603)
- Roderick John Clifton-Bligh (ORCID: https://orcid.org/0000-0002-1545-0368)
- Anand Vaidya (ORCID: https://orcid.org/0000-0002-0314-9252)
- Enol Álvarez-González (ORCID: https://orcid.org/0000-0002-6701-9836)
- Lucía Celada (ORCID: https://orcid.org/0000-0002-3058-7231)
- José Luís Llorente (ORCID: https://orcid.org/0000-0001-7713-5526)
- Nelly Burnichon (ORCID: https://orcid.org/0000-0001-7972-5845)
- Igor I. Adameyko (ORCID: https://orcid.org/0000-0001-5471-0356)
- Paolo Giovanni Nuciforo (ORCID: https://orcid.org/0000-0003-1380-0990)
- Alexandre Buffet (ORCID: https://orcid.org/0000-0002-4742-2708)
- Berta Miranda (ORCID: https://orcid.org/0000-0003-1617-1050)
- Rodrigo Dienstmann (ORCID: https://orcid.org/0000-0001-5997-318X)
- Carlota Arenillas (ORCID: https://orcid.org/0000-0001-7921-9117)
- Alexander R. Opotowsky (ORCID: https://orcid.org/0000-0002-6107-2281)
- Delmar Muniz Lourenço (ORCID: https://orcid.org/0000-0003-1147-4159)
- Patricia L. M. Dahia (ORCID: https://orcid.org/0000-0002-7757-370X)
- Laura Dos (ORCID: https://orcid.org/0000-0001-5821-4501)
- Amelia Oleaga (ORCID: https://orcid.org/0000-0002-8244-1840)
- Rita Maria Regojo Zapata (ORCID: https://orcid.org/0000-0003-4486-4647)
- Cristina Álvarez-Escolá (ORCID: https://orcid.org/0000-0003-4448-7941)
- Ana González García (ORCID: https://orcid.org/0000-0002-8596-767X)
- Maria Adelaide Albergaria Pereira
- María‐Dolores Chiara (ORCID: https://orcid.org/0000-0002-1112-1583)
- Joaquín Rueda Soriano (ORCID: https://orcid.org/0000-0002-6187-9317)
- Ángel M. Martínez‐Montes (ORCID: https://orcid.org/0000-0003-1461-4516)
- José Ruiz-Cantador (ORCID: https://orcid.org/0000-0002-0422-6491)
Institutions
- Universitat de Vic - Universitat Central de Catalunya (ES)
- Hebron University (PS)
- Universitat Autònoma de Barcelona (ES)
- Brigham and Women's Hospital (US)
- Cincinnati Children's Hospital Medical Center (US)
- Boston Children's Hospital (US)
- The University of Sydney (AU)
- New South Wales Department of Health (AU)
- Mayo Clinic (US)
- Inserm (FR)
- University of Tennessee Health Science Center (US)
- Universidad de Oviedo (ES)
- Oregon Health & Science University (US)
- The University of Texas at San Antonio Health Science Center (US)
- Universitat Pompeu Fabra (ES)
- Université Paris Cité (FR)
- Royal North Shore Hospital (AU)
- Hospital Universitario La Paz (ES)
- Instituto de Salud Carlos III (ES)
- Karolinska Institutet (SE)
- Hospital Universitari i Politècnic La Fe (ES)
- UNSW Sydney (AU)
- Sorbonne Université (FR)
- St Vincent's Hospital Melbourne (AU)
- St Vincent's Hospital Sydney (AU)
- Spanish National Cancer Research Centre (ES)
- Centre de Recherche des Cordeliers (FR)
- Hospital de Basurto (ES)
- St Vincent’s Private Hospital Sydney (AU)
- Hôpital Européen Georges-Pompidou (FR)
- Vall d'Hebron Institut de Recerca (ES)
- Hôpital Européen (FR)
- Migration Institute of Australia (AU)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Universitario Central de Asturias (ES)
- Nanomaterials and Nanotechnology Research Center (ES)
- Complexo Hospitalario Universitario A Coruña (ES)
- ERN GUARD-Heart (NL)
- Hospital Universitário da Universidade de São Paulo (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Mayo Clinic in Florida (US)
- CIBBIM-Nanomedicine (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Instituto de Investigación Biomédica de A Coruña (ES)
- Instituto de Investigación de Enfermedades Raras (ES)
- Hospital Universitario Ramón y Cajal (ES)
- University Hospital Carl Gustav Carus (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0943
- Citations
- 5
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- Fundación BBVA
- Fundación Cellex
- Neuroendocrine Tumor Research Foundation
- Ministerio de Ciencia, Innovación y Universidades
- Centres de Recerca de Catalunya
- Paradifference foundation
- European Cooperation in Science and Technology
- Centro de Investigación Biomédica en Red de Cáncer
- Fundación Fero
- Instituto de Salud Carlos III