Evaluation and clinical characteristics of anxiety, depression, and sleep quality among adult patients with seizure clusters

A total of 330 adult patients with epilepsy were included. Statistically significant differences (p < 0.05) were found between the patients with SCs and without groups in terms of age at first onset, etiology, semiology distribution, imaging and EEG results, therapy, and prognosis. SC patients had significantly higher GAD-7, NDDI-E, and PSQI average total scores than in the Non-Seizure Cluster (NSC) group. (p < 0.001), and the distribution of related factors varying by age and daily seizure frequency. Patients with SCs had shown lower objective support, including material support, social networks, and group relationships than the control group SIGNIFICANCE: SCs are a type of clinical emergency. Patients with SCs are more susceptible to anxiety, depression, poor sleep quality and social burden, requiring proactive intervention and mental health management. This study is registered with the Chinese Clinical Trials Registry (identifier: ChiCTR2400088157).