Circulating Tumor DNA and Response to Cisplatin-based Chemotherapy in Patients with Metastatic Urothelial Carcinoma Enrolled in CALGB 90601 (Alliance)
We looked at the link between tumor DNA present in blood and outcomes after chemotherapy for patients with advanced bladder cancer. Higher amounts of tumor DNA in blood and mutations in specific cancer genes were linked to worse survival. The results may help in the design of new studies to improve survival for patients with advanced bladder cancer.This trial is registered on ClinicalTrials.gov as NCT00942331.
Authors
- Karissa Whiting (ORCID: https://orcid.org/0000-0002-4683-1868)
- Venkatraman Seshan (ORCID: https://orcid.org/0000-0002-9258-2698)
- Himisha Beltran (ORCID: https://orcid.org/0000-0003-3259-2226)
- Ronak H. Shah (ORCID: https://orcid.org/0000-0001-9042-6213)
- Jonathan E. Rosenberg (ORCID: https://orcid.org/0000-0003-2637-4249)
- Susan Halabi (ORCID: https://orcid.org/0000-0003-4135-2777)
- Jennifer H. Milbank (ORCID: https://orcid.org/0000-0001-5091-8053)
- Ashley Marie Regazzi (ORCID: https://orcid.org/0000-0002-6019-1852)
- Dean F. Bajorin (ORCID: https://orcid.org/0000-0003-4001-7088)
- Gopa Iyer
- Brendan J. Guercio (ORCID: https://orcid.org/0000-0001-6296-2473)
- Karla V. Ballman (ORCID: https://orcid.org/0000-0002-4492-0357)
- Michael J. Morris (ORCID: https://orcid.org/0000-0001-8802-9147)
- Michael F. Berger
- David B. Solit (ORCID: https://orcid.org/0000-0002-6614-802X)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Cornell University (US)
- Dana-Farber Cancer Institute (US)
- Mayo Clinic in Florida (US)
- Molecular Oncology (United States) (US)
- Data Management (Italy) (IT)
- Weill Cornell Medicine (US)
- University of Rochester (US)
Publication Details
- Journal
- European Urology Open Science
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1016/j.euros.2025.03.009
- Citations
- 1
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01