Grin2a Hypofunction Impairs Spatial Working Memory and Disrupts Hippocampal Network Oscillations and Excitatory-Inhibitory Balance
This study highlights the critical role of GluN2A-containing NMDA receptors in maintaining hippocampal network synchrony. Impairments in network synchrony and E/I balance within the hippocampus may contribute to cognitive deficits observed in <i>Grin2a</i>-related disorders such as schizophrenia, epilepsy, and intellectual disability.
Authors
- Kevin S. Jones (ORCID: https://orcid.org/0000-0001-5281-1591)
- Dominique L. Pritchett (ORCID: https://orcid.org/0000-0003-1187-1162)
- Hassan Hosseini (ORCID: https://orcid.org/0000-0002-2702-6994)
- Sky Evans-Martin
- Emma Bogomilsky
Institutions
- Howard University (US)
- University of Michigan (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100500
- Citations
- 3
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- Broad Institute