Longitudinal Evaluation of Immune Checkpoint Inhibitor‐Induced Fatigue Syndrome by Rest, Stress, and Speckle‐Tracking Strain Echocardiography
In patients starting ICI, statistically-significant reductions in cardiac systolic function (LVOT VTI) and peak HR were observed, with nearly one-third unable to achieve peak exercise at 6 months. This finding, combined with reported fatigue and lack of changes to biventricular systolic functional measures, suggests induced functional cardiac limitations are due to deconditioning, rather than cardiotoxicity.
Authors
- Dwight Bibby
- Adil Daud (ORCID: https://orcid.org/0000-0002-6617-8421)
- Andrew Y. Chang (ORCID: https://orcid.org/0000-0002-3009-6678)
- Nelson B. Schiller (ORCID: https://orcid.org/0000-0001-5489-4378)
- Joan F. Hilton (ORCID: https://orcid.org/0000-0003-2452-4274)
- Leila Haghighat (ORCID: https://orcid.org/0000-0002-7857-0789)
- Katy K. Tsai
- Mandar A. Aras
- Christiane Abouzeid
- Qizhi Fang
Institutions
- Sutter Health (US)
- University of Southern California (US)
- University of California, San Francisco (US)
- Sutter Medical Center (US)
- Yale University (US)
Publication Details
- Journal
- Echocardiography
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/echo.70158
- Citations
- 1
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Mount Zion Health Fund
- University of California, San Francisco