Study of skin microbiota in patients with chronic lichenoid parapsoriasis

Introduction. The article presents the results of a study of differences in the skin microbiota of patients with PLC compared with healthy individuals. Aim. To study the composition of the skin microbiota in patients with chronic lichenoid pityriasis compared with healthy individuals. Materials and methods. The objects of the study were 30 patients with PLC and 30 patients with PLEVA, who were under observation in the dermatological hospital department of the State Budgetary Institution of Healthcare in Ufa (comparison group – 30 healthy individuals). All participants were examined and clinically examined by a dermatovenereologist with the clarification of anamnestic data, determination of the form of the PL. Results. Were examined 30 patients with CLP (group 1) and 30 healthy people (group 2). Un sanitized foci of infection (caries, tonsillitis, sinusitis, etc.) were more often detected in group 1 – in 28 (93.3%) vs. 10 (33.3%) individuals in groups 1 and 2 (p < 0.05). The concentration of CIC in group 1 was significantly higher than in the control group (112.2 vs. 54.9 IU/ml, p < 0.05), as well as CD8+ lymphocytes (27.6 vs. 14.0%, p = 0.042). The most common manifestations of the microflora of patients with CLP are Staph. epidermidis (26.6%), Corynebacteriu m (23.3%) and Candida albicans (26.6%), in the control group – Staph. epidermidis (70.0% of cases), Staph. hominis (30.0%) and Corynebacterium (13.3%). Conclusion. In patients with lichenoid pityriasis, there is a diversity of the main representatives of the skin microbiota, which has some differences from the microbiota of healthy individuals. There are differences in contamination by various representatives of the microbiome in the affected and intact areas. These data may indicate an association of changes in the skin microbiota in PLC with the progression of the disease and the expression of certain subpopulations of T-lymphocytes.