Macrophage Changes and High‐Throughput Sequencing in Aging Mouse Intervertebral Disks
Disk senescence and reduced height in aged mice are linked to upregulated expression of senescence-associated phenotypes and macrophage polarization markers. These findings suggest that macrophages and differential gene expression play key roles in age-related IVD degeneration, indicating that they can be used as potential targets for therapeutic intervention.
Authors
- Yong‐Long Chen
- Jiong‐Hui Chen
- Zhichao Yang (ORCID: https://orcid.org/0000-0002-8939-9219)
- Cheng Jiang (ORCID: https://orcid.org/0000-0002-8735-1254)
- Xiao‐Chuan Li (ORCID: https://orcid.org/0000-0002-9215-0190)
- Wang Wei
- Zhen‐Wu Zhang
- Jun Li (ORCID: https://orcid.org/0009-0004-1683-5130)
Institutions
- Guangdong Medical College (CN)
- First People's Hospital of Chongqing (CN)
- Gaozhou People's Hospital (CN)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1002/jsp2.70061
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Guangdong Province