Effects of Verteporfin on Interstitial Fluid Flow-Induced Fibrotic Transdifferentiation of Human Tenon Fibroblasts
Slow interstitial fluid flow activates the YAP/TAZ pathway. VP exerts antifibrotic potential by reducing morphologic changes and suppressing the expression of ECM genes induced by flow. Therefore, YAP/TAZ inhibition may exhibit therapeutic potential after glaucoma filtration surgery by inhibiting fibrotic changes induced by mechanical stimuli.
Authors
- Günther Schlunck (ORCID: https://orcid.org/0000-0002-0355-7766)
- Thomas Reinhard (ORCID: https://orcid.org/0000-0002-4937-6936)
- Cornelius Wiedenmann (ORCID: https://orcid.org/0000-0002-3072-6182)
- Charlotte Gottwald
- Kosovare Zeqiri
- Janne Frömmichen
- Emma Bungert
- Jeanne Ströble
- M. Gläser
- Jan Lübke
Institutions
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1167/iovs.66.4.17
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Albert-Ludwigs-Universität Freiburg
- Université de Fribourg
- Deutsche Ophthalmologische Gesellschaft