Activating Striatal Parvalbumin Interneurons to Alleviate Chemotherapy‐Induced Muscle Atrophy
Activation of PV interneurons significantly alleviates cisplatin-induced motor deficits and muscle atrophy by improving spontaneous motor activity, NMJ integrity and muscle function. It has a similar effect to short-term exercise and may offer a promising therapeutic strategy for mitigating chemotherapy-induced muscle atrophy.
Authors
- Z. Shen (ORCID: https://orcid.org/0000-0003-2208-4287)
- Jun Hu (ORCID: https://orcid.org/0000-0002-0168-370X)
- Junlong Sun (ORCID: https://orcid.org/0000-0002-4482-2925)
- Yuqing Yan (ORCID: https://orcid.org/0009-0002-4436-0545)
- Jingyuan Liu (ORCID: https://orcid.org/0000-0001-5624-1258)
- Yongjun Zheng (ORCID: https://orcid.org/0000-0001-6554-1690)
Institutions
- Shanghai University of Sport (CN)
- Fudan University (CN)
- Huadong Hospital (CN)
- Shanghai University of Medicine and Health Sciences (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/jcsm.13782
- Citations
- 3
- Primary Topic
- Nerve Injury and Rehabilitation
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China