COL4A1 Promotes Gastric Cancer Progression by Regulating TumorInvasion, Tumor Microenvironment and Drug Sensitivity
This study established COL4A1 as a prognostic marker and a potential therapeutic target in gastric cancer. Our findings demonstrate that COL4A1 enhances tumor progression and multidrug resistance while inhibiting antitumor immunity. These results underscore the significance of COL4A1 in gastric cancer and suggest its potential for developing targeted therapies.
Authors
- Jinguo Zhang (ORCID: https://orcid.org/0000-0001-9952-9307)
- Yuntian Li
- Wei Jia (ORCID: https://orcid.org/0000-0002-7301-3297)
- Xiaojun Qian (ORCID: https://orcid.org/0000-0002-0883-0987)
- Yubei Sun
- Jian Chen (ORCID: https://orcid.org/0000-0003-0759-7201)
Institutions
- University of Science and Technology of China (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2025-04-08
- DOI
- https://doi.org/10.2174/0109298673351943250314074632
- Citations
- 5
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 8.11