Metabolomic Profiling Reveals Distinct Pathways in Degeneratedand Non-degenerated Rotator Cuff Tears: Implications forPathogenesis and Treatment
These findings suggest that metabolomic alterations may be associated with the development of RCTs, with changes in tyrosine metabolism, ferroptosis, and lipid metabolism potentially contributing to muscle degeneration and inflammation. Identified disruptions in steroidogenesis provide new insights into the role of hormonal factors in RCT development. Understanding these metabolic pathways is clinically relevant in sports medicine, as it enables targeted therapies and personalized treatment strategies, ultimately enhancing recovery and improving outcomes for athletes.
Authors
- Ozan Kaplan (ORCID: https://orcid.org/0000-0001-7429-9349)
- Mustafa Özer (ORCID: https://orcid.org/0000-0002-4199-836X)
- Hasan Rüzgar (ORCID: https://orcid.org/0000-0003-1756-8383)
- Mustafa Çelebi̇er (ORCID: https://orcid.org/0000-0001-7712-5512)
- Bilge Başak Fidan (ORCID: https://orcid.org/0000-0002-0213-5887)
- Feza Korkusuz (ORCID: https://orcid.org/0000-0001-9486-3541)
- Onur Bilge (ORCID: https://orcid.org/0000-0002-7682-0537)
- Emine Koç
- Furkan Bülbül (ORCID: https://orcid.org/0009-0002-7667-010X)
Institutions
- Necmettin Erbakan University (TR)
- Hacettepe University (TR)
Publication Details
- Journal
- Current Molecular Medicine
- Published
- 2025-04-07
- DOI
- https://doi.org/10.2174/0115665240364302250320025755
- Citations
- 1
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01