Development of Potential Pharmacological Targets to Normalize GeneExpression in Islets of Type 2 Diabetic Patients

We identified some alterations in the pancreas of patients with T2D, ten hub genes, and five experimental drugs that could potentially correct gene expression abnormalities. However, further studies are required to validate these results.

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Journal
Current Medicinal Chemistry
Published
2025-04-07
DOI
https://doi.org/10.2174/0109298673352470250312082922
Primary Topic
Pancreatic function and diabetes
Type
article
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article

Development of Potential Pharmacological Targets to Normalize GeneExpression in Islets of Type 2 Diabetic Patients

Fernando Martínez–Esquivias, Juan Manuel Guzmán‐Flores, Viridiana Basaldúa-Maciel
Current Medicinal Chemistry
Pancreatic function and diabetes
article

Development of Potential Pharmacological Targets to Normalize GeneExpression in Islets of Type 2 Diabetic Patients

Fernando Martínez–Esquivias, Juan Manuel Guzmán‐Flores, Viridiana Basaldúa-Maciel
article en

Abstract

We identified some alterations in the pancreas of patients with T2D, ten hub genes, and five experimental drugs that could potentially correct gene expression abnormalities. However, further studies are required to validate these results.

Current Medicinal ChemistryVol. 32
Universidad de Guadalajara (MX)
Good health and well-being
Openalex Percentile: Top 88%
Pancreatic function and diabetes
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Development of Potential Pharmacological Targets to Normalize GeneExpression in Islets of Type 2 Diabetic Patients — Fernando Martínez–Esquivias, Juan Manuel Guzmán‐Flores, et al. · Current Medicinal Chemistry (2025) | TGRS Research Map | TGRS