Impact of myocardial phenotype on optimal atrioventricular delay settings during biventricular and left bundle branch pacing at rest and during exercise: insights from a virtual patient study
Simulations show that hypocontractility and stiffness reduce the effect of AVD optimization on SV but enhance its benefit in lowering mLAP. Notably, virtual patients with stiff ventricles experience greater benefits from AVD optimization during exercise compared to resting conditions. Furthermore, nsLBBP provides more favourable improvements in mLAP than BiVP.
Authors
- Nick van Osta (ORCID: https://orcid.org/0000-0002-8927-9110)
- Ahmed S Beela
- Joost Lumens (ORCID: https://orcid.org/0000-0001-8129-7384)
- Lieven Herbots (ORCID: https://orcid.org/0000-0001-7784-3610)
- Frits W. Prinzen (ORCID: https://orcid.org/0000-0001-8917-9032)
- Claudia A Manetti (ORCID: https://orcid.org/0009-0008-3763-2972)
- Tammo Delhaas (ORCID: https://orcid.org/0000-0001-6897-9700)
Institutions
- Suez Canal University (EG)
- University Medical Center (US)
- Maastricht University (NL)
- Jessa Hospital (BE)
- Hartcentrum Hasselt (BE)
- Biomedical Research Institute (US)
- Hasselt University (BE)
Publication Details
- Journal
- EP Europace
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1093/europace/euaf082
- Citations
- 3
- Primary Topic
- Cardiac pacing and defibrillation studies
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- European Commission