Tumor-specific CXCR6 positive precursor CD8+ T cells mediate tumor control in metastatic melanoma
In our study, a subset of antigen-specific CXCR6-expressing Texp cells was observed within the metastatic tissue. The cells served as a crucial source of effector-like Tex cells and exerted direct cytotoxic effects on tumor cells. Adoptive transfer of CXCR6<sup>+</sup> Texp cells effectively mitigated lung metastasis in mice. This study helps elucidate the role of Texp cells in metastasis, thereby offering novel insights into enhancing the efficacy and durability of immunotherapy.
Authors
- Yaqin Zhang (ORCID: https://orcid.org/0000-0001-8804-8882)
- Zhiming Chen (ORCID: https://orcid.org/0000-0001-8308-5270)
- Yang Song (ORCID: https://orcid.org/0000-0002-7385-3595)
- Gang Chen (ORCID: https://orcid.org/0000-0002-3507-1218)
- Yiqing Wang (ORCID: https://orcid.org/0000-0003-0873-2831)
- Feng Miao (ORCID: https://orcid.org/0000-0001-7619-4620)
- Ning Wu (ORCID: https://orcid.org/0000-0002-5458-8327)
- Ji Chen (ORCID: https://orcid.org/0000-0002-5308-9307)
- Yongjun Zhu
Institutions
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1007/s13402-025-01040-1
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China
- Fudan University