Bio Python Application for Comparative Analysis of COVID-19 Virus Genome with Other Calamitous Genome

Since last decade mankind has been adversely affected due to prominent viruses such as Ebola, SARS-CoV and MERS. Recently COVID-19 has created a worldwide pandemic situation resulting in huge losses of human lifes. To safeguard humans and prevent economical losses the deep understanding of genetic structure is essential for developing proper medicine/vaccination.The present workanalyses and compare the genomic structure of COVID-19 virus with other calamitous viruses’trough pairwise comparison of local and global alignment of DNA sequences, measuring length of DNA sequence, Hamming Distance, GC content. Further Bio python has been used for the study and the results have been presented in the form of 3D structures and Dot plots. The result helps in understanding the virus relationships.It has been observed that COVID-19 and SARS have an 89% similarity which means both are the same genus and belong to the same family, COVID-19 and MERS have a 71% similarity, COVID-19 and Ebola have a 58% similarity, COVID-19 and HIV have a 61% similarity while COVID-19 and swine flu have a 62% similarity content. Since, Ebola, HIV, and swine flu have less percentage of similarity with COVID-19 they belong to a different family of viruses. This research emphasis on finding the similarities among the viruses and helps the scientist to develop appropriate medicine.