Amyloid precursor protein and presenilin‐1 knock‐in immunodeficient mice exhibit intraneuronal Aβ pathology, microgliosis, and extensive neuronal loss
A novel Alzheimer's disease (AD) knock-in (KI) mouse was developed and characterized on an immunodeficient NOG background. The model provides a platform for human immune studies and the evaluation of immunotherapies for AD. The KI mice demonstrate intraneuronal Aβ deposits and amyloid-associated microglial reactions. KI mice demonstrate extensive neuronal loss. Human immune reconstitution enables studies of infectious AD co-morbidities, such as the human immunodeficiency and herpes simplex viruses.
Authors
- Tsuneya Ikezu (ORCID: https://orcid.org/0000-0002-3979-8596)
- Susmita Sil (ORCID: https://orcid.org/0000-0001-8941-985X)
- Jatin Machhi (ORCID: https://orcid.org/0000-0001-6457-2022)
- Shaurav Bhattarai (ORCID: https://orcid.org/0000-0002-5687-0705)
- Larisa Y. Poluektova (ORCID: https://orcid.org/0000-0001-7339-8732)
- Emma G. Foster (ORCID: https://orcid.org/0000-0003-1241-1918)
- Rana Kadry
- Yaman Lu
- Mohit Kumar (ORCID: https://orcid.org/0009-0003-4717-610X)
- Howard E. Gendelman (ORCID: https://orcid.org/0000-0002-7831-0370)
- R. Lee Mosley (ORCID: https://orcid.org/0000-0002-4241-6149)
- Roshan Sapkota (ORCID: https://orcid.org/0000-0002-2809-952X)
- Shefali Srivastava (ORCID: https://orcid.org/0009-0008-0673-9654)
- Pravin Yeapuri
Institutions
- Jacksonville College (US)
- Mayo Clinic in Florida (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.70084
- Citations
- 9
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- National Institutes of Health