Single-cell transcriptomic analysis identified resistant MDSCs and a stress-tolerant gene co-expression network as common MDSC features across multiple disease settings
These results demonstrate the importance of the combined roles of inflammation and cellular stress in shaping the features of M-MDSCs and highlight cellular resilience represented by rMDSCs and the role of stress-tolerant features in defining common MDSC features.
Authors
- Alyssa D. Gregory (ORCID: https://orcid.org/0000-0002-0392-7202)
- Jinming Song (ORCID: https://orcid.org/0000-0001-5642-1451)
- Julia L Conroy (ORCID: https://orcid.org/0009-0007-4725-0698)
- Patricia Loughran (ORCID: https://orcid.org/0000-0001-9375-1724)
- Wei Chen (ORCID: https://orcid.org/0000-0002-5255-4166)
- Tianmeng Chen (ORCID: https://orcid.org/0000-0003-0451-5557)
- Julia Hughes
- Timothy R. Billiar
Institutions
- University of Pittsburgh (US)
- Moffitt Cancer Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1565211
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health