Mutational profile of pfdhfr, pfdhps, pfmdr1, pfcrt and pfk13 genes of P. falciparum associated with resistance to different antimalarial drugs in Osun state, southwestern Nigeria
There was no evidence of parasite genomes harbouring multilocus mutations conferring multidrug resistance, although evidence of a validated (C580Y) and a candidate (R515K) mutation in pfk13 gene, high frequency pfdhfr mutant alleles and high variability of pfdhps haplotypes were found in this study, which provides a baseline information essential in monitoring P. falciparum resistances.
Authors
- Thuy‐Huong Ta‐Tang (ORCID: https://orcid.org/0000-0001-7058-4839)
- Agustín Benito (ORCID: https://orcid.org/0000-0001-8229-5540)
- Vicenta González Mora
- Irene Molina‐de la Fuente (ORCID: https://orcid.org/0000-0003-3053-0355)
- Alexandra Martín Ramírez (ORCID: https://orcid.org/0000-0002-1132-2211)
- Pedro Berzosa (ORCID: https://orcid.org/0000-0002-8768-717X)
- Nathalie Lara
- Luz García
- Sulaiman Adebayo Nassar
- Akeem Abiodun Akindele
Institutions
- Universidad Complutense de Madrid (ES)
- Universidad de Alcalá (ES)
- Instituto de Salud Carlos III (ES)
- Centro Nacional de Medicina Tropical (ES)
- Centro de Investigación Biomédica en Red (ES)
- Instituto de Investigación de Enfermedades Raras (ES)
- Ladoke Akintola University of Technology (NG)
Publication Details
- Journal
- Tropical Medicine and Health
- Published
- 2025-04-08
- DOI
- https://doi.org/10.1186/s41182-025-00732-6
- Citations
- 4
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Instituto de Salud Carlos III