Using individualized structural covariance networks to analyze the heterogeneity of cerebral small vessel disease with depressive states

This study analyzed the IDSCNs between CSVD+D patients and HCs, which may indicate that the individual structural covariance aberrations between the caudate nucleus and cerebellum may contribute to depression in CSVD patients. Additionally, the higher total CSVD imaging burden of CSVD patients may indicate more severe depression. This finding suggests that early magnetic resonance imaging (MRI) assessment in CSVD patients may facilitate the early identification of depressive states and their severity in the near future.