MDM2 inhibitor induces apoptosis in colon cancer cells through activation of the CHOP-DR5 pathway, independent of p53 phenotype
These findings reveal a novel p53-independent apoptotic mechanism of Nutlin-3a involving ER stress and death receptor signaling. This pathway highlights Nutlin-3a's potential as an adjuvant therapy for colon cancer, even in p53-mutated tumors, by enhancing chemotherapeutic efficacy through extrinsic apoptosis.
Authors
- Aimin Yue
- Baoru Gu
- Weiyue Xia
- Shenggen Wang
- Yuhou Shen
- Manman Lu (ORCID: https://orcid.org/0000-0001-7517-6551)
- Yingli Ren (ORCID: https://orcid.org/0000-0002-2136-0123)
- Sijia Feng (ORCID: https://orcid.org/0000-0002-9115-1618)
- Na Li (ORCID: https://orcid.org/0000-0001-9171-5367)
- Jiateng Zhong (ORCID: https://orcid.org/0000-0003-0822-2815)
- Yongxi Zhang (ORCID: https://orcid.org/0000-0003-3840-5209)
Institutions
- First Affiliated Hospital of Xinxiang Medical University (CN)
- Xinxiang Central Hospital (CN)
- Henan Polytechnic University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fphar.2025.1508421
- Citations
- 1
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.05