Synergistic chemo-immunotherapy for osteosarcoma via a pH-responsive multi-component nanoparticle system
The combination of ICD induction, innate immune activation, and checkpoint blockade reprogrammed the tumor microenvironment, amplifying anti-tumor immune responses. These results demonstrate the potential of this multifunctional nanoparticle platform as an effective immunochemotherapeutic strategy for osteosarcoma, offering enhanced therapeutic efficacy and reduced systemic toxicity.
Authors
- Xuan Sun (ORCID: https://orcid.org/0000-0001-6638-5159)
- Xianwen Yan
- Yuanfan Li
- Dapeng Li (ORCID: https://orcid.org/0000-0002-9198-082X)
- Wenchao Zhang (ORCID: https://orcid.org/0000-0002-6227-3464)
- Fan Wu (ORCID: https://orcid.org/0000-0001-7763-8852)
- Jie Cang
Institutions
- Jiangsu University (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Jintan People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-08
- DOI
- https://doi.org/10.3389/fphar.2025.1584245
- Citations
- 2
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Jiangsu University