The striatum is an early, accurate indicator of amyloid burden using [ <sup>11</sup> C]PiB in Down syndrome: Comparison of two radiotracers
Striatal amyloid is detectable 3.4 years before the cortex using PiB PET in DS. Florbetapir PET does not detect early striatal amyloid accumulation in DS. White matter can be used as reference region in longitudinal florbetapir PET. SILA trajectory models can be used to compare regional estimates for age of onset.
Authors
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Benjamin L. Handen (ORCID: https://orcid.org/0000-0001-9550-1665)
- Tim D. Fryer (ORCID: https://orcid.org/0000-0003-1555-9790)
- Adam M. Brickman (ORCID: https://orcid.org/0000-0002-5125-8226)
- Charles M. Laymon (ORCID: https://orcid.org/0000-0002-5966-7219)
- Tobey J. Betthauser (ORCID: https://orcid.org/0000-0001-8856-1352)
- Bradley Christian (ORCID: https://orcid.org/0000-0001-5072-3512)
- Brecca Bettcher
- Andrew K McVea (ORCID: https://orcid.org/0009-0008-4525-2793)
- Patrick J. Lao (ORCID: https://orcid.org/0000-0003-2243-3547)
- Matthew Zammit (ORCID: https://orcid.org/0000-0001-8966-8397)
- Shahid Zaman (ORCID: https://orcid.org/0000-0003-1639-6014)
- H. Diana Rosas (ORCID: https://orcid.org/0000-0001-9360-7511)
- Sigan L. Hartley (ORCID: https://orcid.org/0000-0002-0186-6282)
- Alexandra H DiFilippo (ORCID: https://orcid.org/0000-0003-0003-8968)
- Max McLachlan (ORCID: https://orcid.org/0000-0003-1801-7233)
- Elizabeth Head (ORCID: https://orcid.org/0000-0003-1115-6396)
- Julie C. Price
- Beau M. Ances (ORCID: https://orcid.org/0000-0003-3862-7397)
- Mark E. Mapstone (ORCID: https://orcid.org/0000-0003-0280-8057)
- David B. Keator (ORCID: https://orcid.org/0000-0001-5281-5576)
- Sterling C. Johnson
- Charles K. Stone
- ACIP Investigators
- Lisette LeMerise (ORCID: https://orcid.org/0009-0001-4443-0673)
- Jeremy Rouanet
Institutions
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- Washington University in St. Louis (US)
- University of Cambridge (GB)
- Massachusetts General Hospital (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.70141
- Citations
- 10
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 18.79
Funders
- National Institutes of Health
- National Institute on Aging
- Eunice Kennedy Shriver National Institute of Child Health and Human Development