Brain cholinergic terminal density utilizing [<sup>18</sup>F]‐fluoroethoxybenzovesamicol PET in adults with Down's syndrome: Relationship to amyloid PET and cognitive performance
Adults with DS display greater cholinergic terminal density in specific ROIs than amyloid-match controls. Adults with DS exhibit a similar pattern of cholinergic terminal density across the brain. The first association of cholinergic terminal density with AD pathology in non-demented adults with DS. Adults with DS display a greater cholinergic terminal decline in association with amyloid accumulation than neurotypically developed age-matched controls. Region-specific cholinergic terminal density associated with cognitive performance in adults with DS.
Authors
- John P. Begnoche (ORCID: https://orcid.org/0000-0001-6111-6662)
- Julie A. Dumas (ORCID: https://orcid.org/0000-0003-2092-334X)
- Michael S. Rafii (ORCID: https://orcid.org/0000-0003-2640-2094)
- Jason K Russell (ORCID: https://orcid.org/0000-0001-6263-1674)
- Alexander C. Conley (ORCID: https://orcid.org/0000-0003-1159-5524)
- PAUL A. NEWHOUSE (ORCID: https://orcid.org/0000-0002-9298-7185)
- Adam J. Rosenberg (ORCID: https://orcid.org/0000-0003-2459-7043)
- Brian D. Boyd (ORCID: https://orcid.org/0000-0002-2055-8154)
- Lealani Mae Y. Acosta (ORCID: https://orcid.org/0000-0002-3704-124X)
- Rachel Schlossberg
- Dann Martin
- Yasmeen Neal
- Allison Stranick
Institutions
- University of Vermont (US)
- University of Southern California (US)
- Autism Research Institute (US)
- Valley Health System (US)
- VA Tennessee Valley Healthcare System (US)
- Geriatric Research Education and Clinical Center (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.70134
- Citations
- 3
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Foundation for the National Institutes of Health
- Alzheimer's Association
- Vanderbilt University
- Vanderbilt Institute for Clinical and Translational Research
- National Institutes of Health
- Intellectual and Developmental Disabilities Research Center
- Vanderbilt Kennedy Center, Vanderbilt University Medical Center
- National Institute on Aging
- National Institute of Child Health and Human Development
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development