Analysis of the characteristics of blood inflammatory cytokines and their influencing factors in acute exacerbations of allergic asthma in children

In pediatric allergic asthma exacerbations, there is a decrease in the activity of Th1 cytokines and an increase in the activity of Th2 cytokines in the peripheral blood, accompanied by enhanced polarization of macrophages towards the M2 phenotype. Respiratory infections and irregular use of ICS are independent risk factors for poor asthma control, whereas SCIT is an independent protective factor against poor asthma control. IL-13 has high accuracy in predicting poor asthma control.