Lactoferrin-derived peptide PXL01 impacts nerve regeneration after sciatic nerve reconstruction in healthy and diabetic rats
Application of PXL01, despite having no impact on macrophages, may improve axonal outgrowth and affects Schwann cell activation in autograft-reconstructed sciatic nerves, as well as conveys neuroprotection (HSP27 expression) in the DRGs of healthy and diabetic GK rats. Diabetes influenced nerve regeneration in such autografts. Therefore, PXL01 is a promising candidate to improve nerve regeneration.
Authors
- Margit Mahlapuu (ORCID: https://orcid.org/0000-0001-8740-8874)
- Raquel Perez
- Lars B. Dahlin (ORCID: https://orcid.org/0000-0003-1334-3099)
- Derya Burcu Hazer (ORCID: https://orcid.org/0000-0003-1881-1146)
Institutions
- Linköping University (SE)
- Malmö University (SE)
- Lund University (SE)
- Göteborgs Stads (SE)
- Skåne University Hospital (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.3389/fcell.2025.1565285
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medicinska Fakulteten, Lunds Universitet