Associations between <i>APOE‐TOMM40 ‘523</i> haplotypes and limbic system white matter microstructure
White matter microstructure (WMM) across limbic tracts important for cognition was measured by diffusion MRI.Black apolipoprotein E (APOE) ε4+ carriers with one copy of TOMM40-'523-S had normal aging WMM metrics across several tracts, including the cingulum bundle, uncinate fasciculus, fornix, and inferior longitudinal fasciculus.White APOE ε3/ε3 carriers with two copies of TOMM40-'523-S had abnormal aging WMM metrics in the cingulum bundle and inferior temporal gyrus.APOE associations with aging may differ in racialized groups due to TOMM40-'523-S copy number.
Authors
- Melissa Lamar (ORCID: https://orcid.org/0000-0001-6130-5543)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Lisa L. Barnes (ORCID: https://orcid.org/0000-0002-0072-9817)
- Derek B. Archer (ORCID: https://orcid.org/0000-0001-8638-0785)
- Kacie Deters
- Konstantinos Arfanakis (ORCID: https://orcid.org/0000-0001-9705-597X)
- Lei Yu (ORCID: https://orcid.org/0000-0002-8837-2022)
- Aditi Sathe
- Katelyn E. Mooney (ORCID: https://orcid.org/0000-0002-8518-6937)
- Ose Kadiri
Institutions
- Rush University Medical Center (US)
- University of California, Los Angeles (US)
- Illinois Institute of Technology (US)
- Vanderbilt University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/dad2.70099
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Rush University
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke
- National Institute of Biomedical Imaging and Bioengineering