Research progress on the mechanism of tryptophan metabolism regulating circadian rhythm

<p indent="0mm">Circadian rhythms are essential for regulating the behavior of organisms and ensuring the proper functioning of organs and cells. Disruptions in circadian rhythms can lead to various disorders, including depression, severe insomnia, and mania, which pose significant risks to human health. Numerous studies have demonstrated that tryptophan and its metabolites are effective in treating chronic conditions associated with circadian rhythm disruptions, such as psychiatric disorders, liver dysfunction, and metabolic disturbances. This review provides an overview of the relationship between tryptophan and its metabolites and circadian rhythms, focusing on the mechanisms by which tryptophan metabolism regulates circadian rhythms and its potential role in circadian disorders. The aim is to offer new insights and evidence for the prevention and treatment of common circadian rhythm-related diseases using tryptophan and its metabolites.