Serum Proteomic Signatures Before the Diagnosis of Rheumatoid Arthritis: Evolving Biologic Pathways and Specific Periods of Disease Development
Autoantibodies and protein signatures evolve in distinct stages before a diagnosis of RA. Furthermore, protein biomarkers may identify biologic pathways relevant to specific stages. These can be further explored to potentially improve prediction of disease onset and identify stage-specific biologic pathways to target with preventive interventions.
Authors
- Michael Mähler (ORCID: https://orcid.org/0000-0002-7919-0948)
- Kevin D. Deane (ORCID: https://orcid.org/0000-0003-2211-4861)
- Christy Bennett (ORCID: https://orcid.org/0000-0003-2569-3803)
- V. Michael Holers (ORCID: https://orcid.org/0000-0002-5634-7746)
- Adam K. Savage (ORCID: https://orcid.org/0000-0003-1913-5485)
- Lynne A. Becker (ORCID: https://orcid.org/0000-0003-1541-4655)
- Jess D. Edison (ORCID: https://orcid.org/0000-0002-5260-0273)
- Troy R. Torgerson (ORCID: https://orcid.org/0000-0003-3489-5036)
- Samir Rachid Zaim (ORCID: https://orcid.org/0009-0007-9256-2324)
- Mark A. Gillespie (ORCID: https://orcid.org/0000-0001-7820-8598)
- Marie L. Feser (ORCID: https://orcid.org/0009-0003-0598-853X)
- Ted R. Mikuls (ORCID: https://orcid.org/0000-0002-0897-2272)
- Xiaojun Li (ORCID: https://orcid.org/0000-0003-0832-9479)
- Joaquín Castilló (ORCID: https://orcid.org/0000-0002-8951-6315)
- LauraKay Moss
Institutions
- Uniformed Services University of the Health Sciences (US)
- Walter Reed National Military Medical Center (US)
- Allen Institute for Immunology (US)
- Inova Design Solutions (United Kingdom) (GB)
- Nova Medical (United States) (US)
- VA Nebraska Western Iowa Health Care System (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1002/art.43175
- Citations
- 3
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 4.08