Elimusertib, a Novel ATR Inhibitor, Induces Anti-tumor Effects through Replication Catastrophe in Breast Cancers
Elimusertib had anti-tumor effects and induced replication catastrophe in breast cancer cells with a high replication rate. Moreover, cells under high DNA replication stress were sensitive to elimusertib. Further studies and treatment strategies with elimusertib are warranted for cancers with a high replication rate.
Authors
- Miso Lee (ORCID: https://orcid.org/0000-0002-3372-705X)
- Sujin Ham
- Jinyong Kim
- Eunice Yoojin Lee (ORCID: https://orcid.org/0000-0001-9342-423X)
- Seongyeong Kim
- Ahrum Min (ORCID: https://orcid.org/0000-0003-3236-838X)
- Sohyeon Kim
- Yujin Kim (ORCID: https://orcid.org/0000-0002-7186-221X)
- Dae-Won Lee
- Mudong Kim
- Seock-Ah Im
- Kyung-Hun Lee
Institutions
- Seoul National University (KR)
- University of California, San Francisco (US)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
Publication Details
- Journal
- Cancer Research and Treatment
- Published
- 2025-04-07
- DOI
- https://doi.org/10.4143/crt.2024.1105
- Citations
- 2
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea