Diastereoselective C(sp<sup>3</sup>)–H acetoxylation of phosphoramidites
Chiral phosphines are important ligands in asymmetric catalysis, yet their potential as directing groups for asymmetric C-H activation remains unexplored due to the oxidative nature of these reactions. We present a Pd-catalysed, P(III)-directed diastereoselective acetoxylation of phosphoramidites, with DFT calculations elucidating their unique reactivity and supporting the proposed reaction mechanism.
Authors
- Georgios Alachouzos (ORCID: https://orcid.org/0000-0002-3058-2246)
- Vanda Dašková (ORCID: https://orcid.org/0000-0002-8696-2993)
- Niklas O. Thiel (ORCID: https://orcid.org/0000-0002-6572-8284)
- Anirban Mondal (ORCID: https://orcid.org/0000-0002-6416-6072)
- Ben L. Feringa (ORCID: https://orcid.org/0000-0003-0588-8435)
- Xiaobing Chen (ORCID: https://orcid.org/0000-0002-7463-7114)
Institutions
- University of Groningen (NL)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc00550g
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00