Electroacupuncture Promotes the Proliferation and Differentiation of Enteric Neural Precursor Cells via the <scp>PTEN</scp>/<scp>PI3K</scp>/Akt/<scp>mTOR</scp> Signaling Pathway in Diabetic Mice
EA alleviates diabetic enteric neuropathy by regulating ENPC dynamics through the PTEN/PI3K/Akt/mTOR signaling pathway. Notably, EA-mediated anti-apoptotic and pro-proliferative effects on ENPCs, and their preferential cholinergic differentiation establish EA as a multimodal therapy that bridges neuromodulation with precursor cell biology, offering an alternative strategy for GI motility disorders.
Authors
- Du Fan (ORCID: https://orcid.org/0000-0003-2704-2131)
- Jinlu Guo (ORCID: https://orcid.org/0009-0002-5097-4543)
- Xin Yang (ORCID: https://orcid.org/0000-0003-1632-2402)
- Shi Liu (ORCID: https://orcid.org/0000-0003-2289-9160)
- H. J. Yang (ORCID: https://orcid.org/0009-0004-8274-9863)
Institutions
- Union Hospital (HK)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1111/nmo.70040
- Citations
- 1
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.81
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China