Common genetic variants do not impact clinical prediction of methotrexate treatment outcomes in early rheumatoid arthritis
Despite an extensive study population with broad multi-modal data, predicting MTX treatment outcomes remains a challenge. Common genetic variants added minimal predictive power over clinical features.
Authors
- Leonid Padyukov (ORCID: https://orcid.org/0000-0003-2950-5670)
- Magnus Boman (ORCID: https://orcid.org/0000-0001-7949-1815)
- Saedís Saevarsdóttir (ORCID: https://orcid.org/0000-0001-9392-6184)
- Johan Askling (ORCID: https://orcid.org/0000-0003-0433-0616)
- Thomas Frisell (ORCID: https://orcid.org/0000-0002-5735-9626)
- Anton Öberg Sysojev (ORCID: https://orcid.org/0000-0003-3221-7979)
- Lars S. Alfredsson (ORCID: https://orcid.org/0000-0003-1688-6697)
- Lars Klareskog (ORCID: https://orcid.org/0000-0001-9601-6186)
- Bénédicte Delcoigne (ORCID: https://orcid.org/0000-0002-2716-5679)
- Helga Westerlind (ORCID: https://orcid.org/0000-0003-3380-5342)
Institutions
- Karolinska University Hospital (SE)
- University of Iceland (IS)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Journal of Internal Medicine
- Published
- 2025-04-06
- DOI
- https://doi.org/10.1111/joim.20087
- Citations
- 1
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Innovationsfonden
- VINNOVA
- Bundesministerium für Bildung und Forschung
- Cancerfonden
- Karolinska Institutet
- Vetenskapsrådet
- NordForsk
- Norges Forskningsråd
- Stiftelsen Konung Gustaf V:s 80-årsfond
- Reumatikerförbundet
- Stiftelsen Professor Nanna Svartz Fond
- European Research Council