Predictive impact of serous retinal detachment in refractory diabetic macular edema

Patients with refractory diabetic macular edema exhibited an increased incidence of baseline morphological characteristics, including serous retinal detachment and foveal eversion. The thickness of serous retinal detachment can serve as reliable quantitative biomarker, with diabetic macular edema displaying a serous retinal detachment thickness > 162 μm having a potential to become refractory in this study. This finding may promote early detection of refractory diabetic macular edema.