Placental and Breastmilk Transfer of Ocrelizumab from Women with Multiple Sclerosis to Infants and the Potential Impact on B-Cell Levels: Primary Analysis of the Prospective, Multicenter, Open-label, Phase IV Studies MINORE and SOPRANINO (PL4.004)
To measure placental and breastmilk transfer of ocrelizumab (OCR) in women with MS and evaluate the impact on B-cell levels in infants potentially exposed during pregnancy (MINORE [NCT04998812]) or breastfeeding (SOPRANINO [NCT04998851]).
Authors
- Dina Jacobs (ORCID: https://orcid.org/0009-0005-6555-8712)
- Ruth Dobson (ORCID: https://orcid.org/0000-0002-2993-585X)
- Catarina Rapôso (ORCID: https://orcid.org/0000-0001-8804-497X)
- Licínio Craveiro (ORCID: https://orcid.org/0000-0002-8841-8035)
- Chien-Ju Lin
- Élisabeth Maillart (ORCID: https://orcid.org/0000-0001-7699-0328)
- Kerstin Hellwig (ORCID: https://orcid.org/0000-0003-4467-9011)
- Riley M. Bove (ORCID: https://orcid.org/0000-0002-2034-8800)
- Thomas F. McElrath (ORCID: https://orcid.org/0000-0003-0857-0107)
- Noemi Pasquarelli (ORCID: https://orcid.org/0000-0002-4780-9056)
- Anna A. Shah (ORCID: https://orcid.org/0000-0002-0580-0248)
- Edith L. Graham (ORCID: https://orcid.org/0000-0001-6862-5531)
- Carlo Pietrasanta (ORCID: https://orcid.org/0000-0002-1019-4422)
- Dusanka Zecevic (ORCID: https://orcid.org/0000-0001-6719-9710)
- Celia Oreja‐Guevara (ORCID: https://orcid.org/0000-0002-9221-5716)
- Agne Kazlauskaite (ORCID: https://orcid.org/0000-0001-9145-8479)
- Heidemarie Kletzl
- Sandra Vukusic
Institutions
- Northwestern University (US)
- Roche (Switzerland) (CH)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Queen Mary University of London (GB)
- University of California, San Francisco (US)
- University of Milan (IT)
- Hospital of the University of Pennsylvania (US)
- Hospital Clínico San Carlos (ES)
- Sorbonne Université (FR)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
- Observatoire Français de la Sclérose en Plaques (FR)
- Roche (United Kingdom) (GB)
- Pitié-Salpêtrière Hospital (FR)
- St. Josef-Hospital (DE)
- Katholisches Klinikum Bochum (DE)
- Rocky Mountain MS Center (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1212/wnl.0000000000211193
- Citations
- 2
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 3.76