GAD65+ Autoimmune Epilepsy Shows Evidence for Hippocampal Hyperexcitability and Inflammation: A Case Study Using HD Spatial Transcriptomics by 10X Genomics (P2-8.015)
To investigate the pathological mechanisms underlying GAD65+ autoimmune epilepsy in a patient with refractory epilepsy, specifically focusing on observed neuronal hyperexcitability in the hippocampus through the use of novel HD Visium technology.
Authors
- Ken Jones (ORCID: https://orcid.org/0000-0002-4646-1000)
- Amanda L. Piquet (ORCID: https://orcid.org/0000-0001-7349-6455)
- Angus Toland
- Samuel J. Guzman (ORCID: https://orcid.org/0000-0001-7029-978X)
- Mary Benson
Institutions
- University of Colorado System (US)
- Children's Hospital Colorado (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1212/wnl.0000000000212516
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00