Upregulation of TRPS1 promotes proliferation, migration, and invasion in ovarian clear cell carcinoma and correlates with poor patient prognosis
TRPS1 is overexpressed in OCCC and is associated with poor prognosis, serving as an independent predictor of patient outcomes. Its elevated expression enhances OCCC cell proliferation, migration, and invasion by regulating proteins involved in the epithelial-to-mesenchymal transition (EMT) pathway. These findings highlight TRPS1 as a critical player in OCCC pathogenesis and a potential biomarker and therapeutic target for disease management.
Authors
- Bingyi Wu (ORCID: https://orcid.org/0000-0002-0176-1667)
- Jie Xing (ORCID: https://orcid.org/0000-0002-1534-3343)
- Shihan Wan
- Jiejie Zhang (ORCID: https://orcid.org/0000-0001-8114-1988)
- Xin Chen (ORCID: https://orcid.org/0000-0002-2628-4027)
- Yanlu Jin
- Aijun Yu (ORCID: https://orcid.org/0000-0002-9212-0362)
- Jingfang Liu (ORCID: https://orcid.org/0000-0003-1908-4454)
- Meijuan Wu (ORCID: https://orcid.org/0000-0001-7893-2287)
- Li Yang (ORCID: https://orcid.org/0000-0001-8833-7473)
Institutions
- Wenzhou Medical University (CN)
- Zhejiang Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1186/s13048-025-01603-8
- Citations
- 2
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.40
Funders
- National Natural Science Foundation of China