Alteration of salivary Streptococcus is associated with statin therapy in older adults: a cohort study
Our multivariate analysis, adjusted for prescribed drug use and non-use, revealed the drug-specific alteration of salivary microbiome composition in Japanese older adults with comorbidities. To our knowledge, this study is the first to described the association of common prescription drug use with salivary microbiome alterations in older adults. Our findings indicated that prescribed drug use is a key factor in understanding the link between salivary microbiome changes and systemic diseases in older adults.
Authors
- Yuna Naraoka (ORCID: https://orcid.org/0000-0002-7745-7944)
- Masahira Hattori (ORCID: https://orcid.org/0000-0001-9467-0344)
- Daisuke Hisamatsu (ORCID: https://orcid.org/0000-0001-9075-8533)
- Wataru Suda (ORCID: https://orcid.org/0000-0002-2861-9724)
- Kyoko Kumagai (ORCID: https://orcid.org/0000-0002-3717-4181)
- Yo Mabuchi (ORCID: https://orcid.org/0000-0001-8008-3966)
- Chihiro Akazawa (ORCID: https://orcid.org/0000-0002-6015-8374)
- Akimi Ikeba
- Yusuke Ogata
- Taku Yamato
Institutions
- Juntendo University (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.3389/fphar.2025.1455753
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science
- RIKEN