Farnesoid X Receptor Regulated Sepsis‐Induced Abnormal Bile Acid Metabolism via the Fibroblast Growth Factor 15/Fibroblast Growth Factor Receptor 4 Pathway
FXR activation was crucial in alleviating sepsis-induced hepatic injury and cholestasis through the FGF15/FGFR signaling pathway, and FXR may act as a potential preventive and intervention target of sepsis.
Authors
- Dan Xu (ORCID: https://orcid.org/0000-0001-6649-1111)
- Jianguo Tang (ORCID: https://orcid.org/0000-0003-1263-7327)
- Liou Huang
- Yuhui Cui
- Ziyang Zhou (ORCID: https://orcid.org/0000-0003-3730-0157)
- Hui Chen (ORCID: https://orcid.org/0000-0001-5684-6628)
Institutions
- Fudan University (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/iid3.70155
- Citations
- 4
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Fudan University