THE LEVEL OF CARDIAC PEPTIDE NT-PROBNP INCREASES DURING PRE-ECLAMPSIA OF PREGNANT WOMEN

The cardiac peptide NT-proBNP, produced and secreted mainly by the left ventricular myocardium, is one of the most important biochemical markers of heart disease. It is known that the concentration of this peptide increases significantly in the blood of patients with heart failure and cases of transplant rejection. However, NT-proBNP levels have not yet been studied in the course of the development of pathological conditions associated with pregnancy, in particular, in pre-eclampsia. The aim of the research. To study the level of cardiac peptide NT-proBNP of pregnant women with pre-eclampsia. The materials and methods. The total number of women examined was 90. 60 (main group) women in their 32-36 weeks of pregnancy complicated by moderate pre-eclampsia were examined. The control group consisted of 30 women of the same gestational age whose pregnancies were uncomplicated. The study was conducted at the Chernivtsi Regional Perinatal Center and Medical Center for Infertility Treatment (Chernivtsi, Ukraine). The MAGLUMI BNP test system (manufacturer: Shēnzhèn New Industries Biomedical Engineering, Shenzhen, China) was used to study NT-proBNP levels; venous blood was collected once from pregnant women on an empty stomach at 8 am. The examinations were conducted at the "Educational and Scientific Laboratory" of the Bukovina State Medical University, which is certified. The study adhered to biomedical ethics guidelines. Statistical processing was performed using the MedCalc software package produced by MedCalc Inc (Ostend, Belgium), and Student's t-test for unequal samples was used. Results of the research. It was revealed that the average level of NT-proBNP in the group of women with pre-eclampsia was likely higher than in the control group (79,5±37,4 pg/mL and 32,0±12,0 pg/mL in the control group, p<0,001). It is reasonable to assume that variations in NT-proBNP levels, specifically an increase in its concentration in blood plasma in pre-eclamptic pregnant women relative to healthy pregnant women, are a highly significant biochemical marker that serves as an indicator of both the condition of cardiomyocytes and the stress on the body's compensatory systems resulting from pre-eclampsia. Conclusions. The level of the cardiac peptide NT-proBNP significantly increases in the blood of women whose pregnancy was complicated by pre-eclampsia. This may, in our opinion, indicate pathological changes in the myocardium caused by an increased load on the heart in the development of hypertension caused by pre-eclampsia in pregnancy.