IN VITRO FERTILIZATION AS A METHOD FOR TREATING ENDOMETRIOSIS-ASSOCIATED INFERTILITY

Introduction. The mechanisms underlying the development and progression of infertility in endometriosis are multifactorial, and the efficacy of various treatment methods remains controversial, highlighting the relevance of this study. Aim of the study. To improve the effectiveness of treatment for endometriosis-associated infertility. Materials and methods. The study included 40 women with endometriosis-associated infertility and 40 women with infertility of other etiologies. In vitro fertilization (IVF) was performed according to standardized protocols. The research was conducted in compliance with the principles of Good Clinical Practice (GCP, 1996), the Council of Europe Convention on Human Rights and Biomedicine (April 4, 1997), the World Medical Association’s Declaration of Helsinki on ethical principles for medical research involving human subjects (1964–2008), and Order No. 690 of the Ministry of Health of Ukraine (September 23, 2009), as amended by Order No. 523 (July 12, 2012). Statistical analysis was performed using standard methods of variational statistics and regression analysis. This work is part of the research project conducted by the Department of Obstetrics and Gynecology, titled “Preservation and Restoration of Reproductive Health in Women and Girls with Obstetric and Gynecological Pathology” (State Registration Number: 0121U110020). Results. A correlation was observed between the number of antral follicles and the anti-Müllerian hormone (AMH) level (R = 0.64 and R = 0.58). A significant decrease in AMH levels was noted in cases of ovarian endometriosis (p < 0.01). Additionally, significant differences were observed in blastocyst quality, specifically in 4AA (p < 0.001) and 4AB (p < 0.038) grades. Conclusions. In vitro fertilization is an effective treatment for endometriosis-associated infertility, with a success rate of 77.5%.