Spatial Analysis of Hereditary Diffuse Gastric Cancer Reveals Indolent Phenotype of Signet Ring Cell Precursors
The marked differences in the genomic and transcriptomic profiles of SRC lesions and advanced DGC support the consideration of SRC lesions as precancers in patients with germline CDH1 mutations.
Authors
- Paul H. McClelland (ORCID: https://orcid.org/0000-0002-3119-6531)
- Michael C. Kelly (ORCID: https://orcid.org/0000-0003-0654-2778)
- Benjamin L. Green (ORCID: https://orcid.org/0000-0002-5772-198X)
- Mark Raffeld (ORCID: https://orcid.org/0000-0002-4039-6957)
- Markku Miettinen (ORCID: https://orcid.org/0000-0002-3282-8107)
- Irene Gullo (ORCID: https://orcid.org/0000-0003-3377-0530)
- Liqiang Xi (ORCID: https://orcid.org/0000-0001-5033-7072)
- Sarah G. Samaranayake (ORCID: https://orcid.org/0000-0002-7056-5635)
- Jonathan M. Hernandez (ORCID: https://orcid.org/0000-0001-7529-0557)
- Cassidy Bowden (ORCID: https://orcid.org/0000-0002-6746-6142)
- Cihan Oguz (ORCID: https://orcid.org/0000-0002-2860-3546)
- Amber F. Gallanis
- Justin Lack (ORCID: https://orcid.org/0000-0003-0584-4010)
- Lauren A. Gamble (ORCID: https://orcid.org/0000-0002-1389-9196)
- Noémi Kedei (ORCID: https://orcid.org/0000-0002-6625-6119)
- Desiree Tillo (ORCID: https://orcid.org/0000-0003-3568-6148)
- Jeremy L. Davis (ORCID: https://orcid.org/0000-0002-6334-6936)
- Theo Heller (ORCID: https://orcid.org/0000-0002-2643-6289)
- Madeline Wong (ORCID: https://orcid.org/0000-0001-5875-1534)
- Andrew M. Blakely (ORCID: https://orcid.org/0000-0002-5013-3851)
- Martha Quezado (ORCID: https://orcid.org/0009-0004-0941-8662)
- Maria O. Hernandez
- Sun A. Kim (ORCID: https://orcid.org/0000-0002-0891-2093)
Institutions
- University of Maryland, Baltimore (US)
- National Institutes of Health (US)
- Universidade do Porto (PT)
- Hospital de São João (PT)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Office of the Director (US)
- Frederick National Laboratory for Cancer Research (US)
- National Institute of Allergy and Infectious Diseases (US)
- National Cancer Institute (US)
- Center for Cancer Research (US)
- National Institutes of Health Clinical Center (US)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
- University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
Publication Details
- Journal
- Molecular Cancer Research
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1158/1541-7786.mcr-24-1039
- Citations
- 5
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 7.36