SYSTEMIC AND LOCAL IMMUNOGLOBULIN STATUS IN PATIENTS WITH ARTHROSO-ARTHRITIS

Although the development of osteoarthritis (OA) does not affect life expectancy, it is one of the leading causes of premature disability after ischemic heart disease and the most common indication for joint arthroplasty. However, the influence of the state of local immunity on the course and outcome of OA remains unknown. The aim was to study the systemic and local (in synovial fluid) Immunoglobulin status in patients with osteoarthritis as a function of patient age. Materials and methods. 96 patients with osteoarthritis who underwent inpatient treatment at the clinic of the National Centre for Rehabilitation and Prosthetics of Persons with Disabilities under the National Agency for Social Protection under the President of the Republic of Uzbekistan were examined. Results and conclusions. The level of total immunoglobulins A, M, G in the synovial fluid of OA patients was higher compared to the control group. The level of IgE in the synovial fluid of group 1 patients is 1.38 times higher than in the control group, while in group 2 patients this difference is 2.21 times. And as we see the production of sIgA is more pronounced in OA patients of group 2, in which this index is significantly higher than the control group in 2.41 times (P˂0.05), while in group 1 patients it is higher only in 1.43 times. Thus, the results of our studies have shown that humoral immunoreactivity is more pronounced at the local level especially in middle-aged patients with osteoarthritis, apparently causing a more protracted and recurrent course of the disease. Conclusions. Thus, the results of our studies have shown that humoral immunoreactivity is more pronounced at the local level especially in middle-aged patients with osteoarthritis, apparently causing a more protracted and recurrent course of the disease.