HIV and Low Omega-3 Levels May Heighten Hippocampal Volume Differences Between Men and Women With Substance Use
HIV may amplify sex differences in hippocampal volumes, disproportionately affecting females. Higher EPA and DHA levels may mitigate these effects, suggesting a protective role against hippocampal atrophy. Further studies are warranted to confirm these findings and explore whether the benefits extend to males with HIV or individuals without HIV.
Authors
- Jiachen Zhuo (ORCID: https://orcid.org/0000-0001-6637-701X)
- Elana Rosenthal (ORCID: https://orcid.org/0000-0001-7234-4871)
- Betty Jo Salmeron (ORCID: https://orcid.org/0000-0003-1699-9333)
- Glenn J. Treisman (ORCID: https://orcid.org/0000-0003-4578-6150)
- Shaoguang Chen
- Raúl N. Mandler (ORCID: https://orcid.org/0000-0002-3320-5374)
- Jag Khalsa (ORCID: https://orcid.org/0000-0002-6534-3616)
- Gary Gerstenblith (ORCID: https://orcid.org/0000-0001-6046-6812)
- Óscar Peña‐Nogales (ORCID: https://orcid.org/0000-0001-7364-9335)
- Xiao Liang (ORCID: https://orcid.org/0000-0001-5476-8304)
- Karl Goodkin
- David D. Celentano (ORCID: https://orcid.org/0000-0002-6472-7706)
- Hong Gu (ORCID: https://orcid.org/0000-0001-6496-0383)
- Shenghan Lai (ORCID: https://orcid.org/0000-0003-1340-9609)
- Vincent A. Magnotta (ORCID: https://orcid.org/0000-0001-8639-5354)
- Thorsten M. Leucker (ORCID: https://orcid.org/0000-0003-2569-6617)
- Hong Lai (ORCID: https://orcid.org/0000-0003-2918-2381)
- Yihong Yang
Institutions
- Boston University (US)
- University of Iowa (US)
- University of Maryland, Baltimore (US)
- National Institutes of Health (US)
- National Institute on Drug Abuse (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- The University of Texas Rio Grande Valley (US)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1016/j.bbih.2025.100988
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- National Institutes of Health
- National Institute on Drug Abuse