Effects of perampanel on bone health in adult patients with epilepsy
This study investigated how PER, a drug used to treat epilepsy, affects bone health in adult patients. Researchers compared 39 patients who were treated with PER for 1 year with 44 patients with newly diagnosed epilepsy. They did not observe significant differences in BMD between the two groups. Some minor changes were observed in thyroid hormone and magnesium levels in the blood, but overall, PER treatment did not have a major effect on bone metabolism or BMD. This study suggested that the short-term use of PER does not significantly affect bone health in people with epilepsy.
Authors
- Chunyan Chen (ORCID: https://orcid.org/0000-0001-9220-4569)
- Wen Luo (ORCID: https://orcid.org/0000-0003-4250-6168)
- Yi Guo (ORCID: https://orcid.org/0000-0001-9490-8172)
- Miao Yu (ORCID: https://orcid.org/0000-0002-9104-4249)
- Yuxuan He (ORCID: https://orcid.org/0009-0002-3005-3421)
- Jing Meng (ORCID: https://orcid.org/0009-0001-6209-4992)
- Nana Zhang (ORCID: https://orcid.org/0000-0003-2023-3330)
- Yi Liang (ORCID: https://orcid.org/0000-0002-0201-9114)
- Liang Yu
Institutions
- University of Electronic Science and Technology of China (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1002/epi4.70038
- Citations
- 4
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 13.98
Funders
- Department of Science and Technology of Sichuan Province