From fabrication to function: Mechanical insights into GelMA microneedle arrays

Gelatin methacryloyl (GelMA) has emerged as a highly suitable material for microneedle (MN) fabrication, offering exceptional biocompatibility and cost-effectiveness. Despite significant advances introduced by GelMA hydrogels, research on GelMA MNs dates back to 2019, yet no review has specifically focused on the manufacturing techniques and mechanical properties of GelMA MNs. For the first time, this review aims to examine the manufacturing methods and mechanical characteristics of GelMA microneedles across various medical applications. Additionally, it discusses different approaches to mechanical characterization and identifies gaps in current manufacturing technologies. The review also explores the potential implications of GelMA MNs in drug delivery and disease diagnosis. Finally, additive manufacturing and hybrid methods, identified as the most promising techniques for future large-scale production, are proposed for further optimization. • GelMA MNs' manufacturing techniques, mechanical characteristics, and medical applications. • Potential implications in drug delivery, disease diagnosis, and treatments. • Potential solutions for large-scale production of MNs. • Correlation between compression and penetration abilities of GelMA MNs. • Dual role of GelMA MNs: swelling for extraction and degradation for delivery.