Methylglyoxal-Induced Glycation of Plasma Albumin: From Biomarker Discovery to Clinical Use for Prediction of New-Onset Diabetes in Individuals with Prediabetes
MGH-ALB219-225 is a novel and stable peptide biomarker of MGO-glycated ALB, whose plasma levels are positively associated with an increased risk of NOD in individuals with prediabetes, independently of traditional risk factors. ClinicalTrials.gov Registration Number: NCT01218061.
Authors
- Chloé Chevalier
- Bertrand Cariou (ORCID: https://orcid.org/0000-0002-1580-8040)
- Cédric Caradeuc (ORCID: https://orcid.org/0000-0002-5958-9732)
- Arsênio Rodrigues Oliveira (ORCID: https://orcid.org/0000-0001-9836-9161)
- Chloé Cloteau (ORCID: https://orcid.org/0000-0002-3527-0698)
- Georges Nouadje
- Gildas Bertho (ORCID: https://orcid.org/0000-0002-4929-763X)
- Nicolas Giraud (ORCID: https://orcid.org/0000-0003-2322-339X)
- Samy Hadjadj (ORCID: https://orcid.org/0000-0001-7110-6994)
- Victoria Pakulska (ORCID: https://orcid.org/0000-0001-7502-1111)
- Maxime Carpentier
- Edith Bigot‐Corbel (ORCID: https://orcid.org/0000-0002-2760-8740)
- Mikaël Croyal (ORCID: https://orcid.org/0000-0002-5449-5817)
- Cédric Le May (ORCID: https://orcid.org/0000-0002-7554-792X)
- Yohann Couté (ORCID: https://orcid.org/0000-0003-3896-6196)
- Marine P. M. Letertre (ORCID: https://orcid.org/0000-0002-7777-1001)
- Matthieu Wargny (ORCID: https://orcid.org/0000-0001-6027-9486)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Cambia (AU)
- Centre Hospitalier Universitaire de Nantes (FR)
- CEA Grenoble (FR)
- Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (FR)
- Sebia (France) (FR)
- Chimie et Interdisciplinarité, Synthèse, Analyse, Modélisation (FR)
- Institut du Thorax (FR)
- Hôpital Laennec (FR)
- GenProMarkers (United States) (US)
- Université Grenoble Alpes (FR)
- Nantes Université (FR)
Publication Details
- Journal
- Clinical Chemistry
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1093/clinchem/hvaf035
- Citations
- 4
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 5.27
Funders
- Agence Nationale de la Recherche
- Direction Générale de l’offre de Soins