Management of <i>Staphylococcus aureus</i> Bacteremia
Staphylococcus aureus bacteremia has a case fatality rate of 15% to 30% and causes 300 000 deaths per year worldwide. Empirical antibiotic treatment should include vancomycin or daptomycin, which are active against MRSA. Once S aureus susceptibilities are known, MSSA should be treated with cefazolin or an antistaphylococcal penicillin. Additional clinical management consists of identifying sites of metastatic infection and pursuing source control for identified foci of infection.
Authors
- Lesley A. Skalla (ORCID: https://orcid.org/0000-0001-5121-6010)
- Thomas L Holland (ORCID: https://orcid.org/0000-0001-7745-9010)
- Steven Y. C. Tong (ORCID: https://orcid.org/0000-0002-1368-8356)
- Vance G. Fowler
Institutions
- The Royal Melbourne Hospital (AU)
- The University of Melbourne (AU)
- Duke University (US)
- Clinical Research Institute (US)
- Peter Doherty Institute (AU)
- Duke Medical Center (US)
- Duke University Hospital (US)
Publication Details
- Journal
- JAMA
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1001/jama.2025.4288
- Citations
- 61
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 85.17